Drug interactions between Propecia and sirolimus
Results for the following 2 drugs: |
|
|---|---|
| Propecia (finasteride) | |
| sirolimus | |
Interactions between your selected drugs
finasteride ⇔ sirolimus
Applies to: Propecia (finasteride) and sirolimus
MONITOR: Coadministration of sirolimus or tacrolimus with other drugs that are also metabolized by CYP450 3A4 may result in elevated plasma concentrations of the macrolide immunosuppressant and/or the coadministered drug(s). The mechanism is decreased drug clearance due to competitive inhibition of CYP450 3A4 activity. Although clinical data are lacking, the possibility of prolonged and/or increased pharmacologic effects of the drugs should be considered.
MANAGEMENT: Pharmacologic responses and/or plasma drug levels should be monitored more closely whenever a macrolide immunosuppressant or another substrate of CYP450 3A4 is added to or withdrawn from therapy, and the dosage(s) adjusted as necessary.
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