propafenone and Mesoridazine Interactions

Interactions between propafenone and Mesoridazine (mesoridazine)

propafenone and mesoridazine (Major Drug-Drug)

CONTRAINDICATED: Mesoridazine can cause dose-related prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in elevated risk of ventricular arrhythmias, including ventricular tachycardia and torsade de pointes, because of additive arrhythmogenic potential related to their effects on cardiac conduction. Mesoridazine overdosage has been associated with ventricular arrhythmias and death.

MANAGEMENT: The concurrent use of mesoridazine with other medications that can prolong the QT interval is considered contraindicated.