Drug interactions between propafenone and Sorine
| Results for the following 2 drugs: |
|---|
| propafenone |
| Sorine (sotalol) |
Interactions between your selected drugs
propafenone ↔ sotalol
Applies to:propafenone and Sorine (sotalol)
GENERALLY AVOID: Coadministration of propafenone with Class IA antiarrhythmic agents may produce additive effects on the QT interval of the electrocardiogram. Theoretically, this may increase the risk of ventricular arrhythmias including torsade de pointes and sudden death. Conflicting information exists as to whether propafenone alone prolongs the QT interval. Some clinicians suggest it does, although data in the medical literature do not support a clinically significant effect of propafenone and other Class IC agents on the QT interval. Moreover, because propafenone prolongs the QRS interval in the electrocardiogram, any changes in the QT interval are difficult to interpret. Nevertheless, proarrhythmic effects including sudden death and life-threatening ventricular arrhythmias such as ventricular fibrillation, ventricular tachycardia, asystole, and torsade de pointes have been associated with its use. Since propafenone has not been extensively studied for use in conjunction with other antiarrhythmic agents or agents that prolong the QT interval, caution may be advisable. In general, the risk of an individual agent or a combination of agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). In addition, the extent of drug-induced QT prolongation is dependent on the particular drug(s) involved and dosage(s) of the drug(s).
MANAGEMENT: Propafenone product labeling for the sustained-release formulation recommends that concomitant use with Class IA and III antiarrhythmic agents be avoided. In addition, these agents should be withheld for at least 5 half-lives prior to dosing with propafenone. Close monitoring of clinical response, ECG, and drug levels is recommended if concomitant use is required. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, palpitations, or syncope.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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