Drug interactions between procainamide and Tagamet
Results for the following 2 drugs: |
|
|---|---|
| procainamide | |
| Tagamet (cimetidine) | |
Interactions between your selected drugs
procainamide ⇔ cimetidine
Applies to: procainamide and Tagamet (cimetidine)
MONITOR: Cimetidine may increase plasma concentrations of procainamide and its active metabolite, NAPA. The mechanism is related to decreased renal tubular secretion of procainamide and NAPA. Increased procainamide serum concentrations may result in ECG changes such as QRS widening or prolonged QT interval and increased risk of arrhythmias such as torsades de pointes.
MANAGEMENT: If these two drugs are given together, serum procainamide and NAPA levels, ECG changes, and hemodynamic status should be closely monitored. Patients should be advised to promptly notify their physician if they experience drowsiness, dizziness, syncope, confusion, tremor, or palpitations. Famotidine and nizatidine do not appear to interact in this manner and may be considered as alternatives.
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