Drug interactions between prednisone and Questran
| Results for the following 2 drugs: |
|---|
| prednisone |
| Questran (cholestyramine) |
Interactions between your selected drugs
cholestyramine ↔ prednisone
Applies to:Questran (cholestyramine) and prednisone
ADJUST DOSING INTERVAL: The coadministration with bile acid sequestrants may delay and/or decrease the absorption of oral corticosteroids. Bile acid sequestrants can bind certain drugs in the intestine to form an insoluble complex that is excreted in the feces. Reduced bioavailability of hydrocortisone has been reported during administration with cholestyramine and colestipol. It is not known if the interaction occurs with other bile acid binding resins such as colesevelam or with corticosteroids other than hydrocortisone, but the possibility should be considered.
MANAGEMENT: Oral corticosteroids should be administered at least one hour before or four to six hours after a cholestyramine or colestipol dose. During concomitant therapy with colesevelam, patients should be monitored for potentially diminished corticosteroid effects.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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