prazosin and Akbeta Interactions

Interactions between prazosin and Akbeta (levobunolol ophthalmic)

prazosin and levobunolol ophthalmic (Moderate Drug-Drug)

MONITOR: The hypotensive effect of beta-blockers and alpha blockers, or adrenergic-neuron-blocking agents, may be additive. Beta-blockers may also blunt reflex tachycardia in response to alpha-blocker-induced hypotension. More severe and more prolonged first-dose effects such as postural hypotension or syncope may result.

MANAGEMENT: Caution is advised if an alpha-adrenergic blocker is added to a patient's beta-blocker regimen. The initial dosage of the alpha-blocker may require reduction. Hemodynamic responses should be monitored during coadministration, especially during the first few weeks of therapy. Patients should be advised to take the alpha-blocker at bedtime and to notify their physician if they experience dizziness or syncope while awake.