Drug interactions between pravastatin and Prezista
| Results for the following 2 drugs: |
|---|
| pravastatin |
| Prezista (darunavir) |
Interactions between your selected drugs
pravastatin ↔ darunavir
Applies to:pravastatin and Prezista (darunavir)
ADJUST DOSE: Coadministration with darunavir/ritonavir may increase the plasma concentrations of pravastatin. The mechanism of interaction has not been described. In 14 study subjects, administration of pravastatin (40 mg single dose) in combination with darunavir/ritonavir (600 mg/100 mg twice a day) increased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of pravastatin by 63% and 81%, respectively, compared to administration without darunavir/ritonavir. Pravastatin AUC increased by up to 5-fold in some patients.
MANAGEMENT: Because high levels of HMG-CoA reductase inhibitory activity in plasma is associated with an increased risk of musculoskeletal toxicity including severe myopathy and rhabdomyolysis, pravastatin should be initiated at the lowest possible dosage when prescribed with darunavir/ritonavir. The dosage may be increased gradually based on clinical response. All patients treated with HMG-CoA reductase inhibitors should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever. Therapy should be discontinued if creatine kinase is markedly elevated in the absence of strenuous exercise or if myopathy is otherwise suspected or diagnosed.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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