potassium-phosphate and Drospirenone Interactions

Interactions between potassium-phosphate(potassium phosphate) and Drospirenone (drospirenone)

potassium phosphate and drospirenone (Moderate Drug-Drug)

MONITOR: The use of drospirenone may potentiate the risk of hyperkalemia in patients receiving chronic treatment with agents that can increase serum potassium such as angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists, potassium-sparing diuretics, heparin, aldosterone antagonists, nonsteroidal anti-inflammatory drugs (NSAIDs), and potassium preparations. Drospirenone has anti-mineralocorticoid activity and may induce hyperkalemia in susceptible patients.

MANAGEMENT: Serum potassium levels should be checked regularly during concomitant therapy with drospirenone and agents that can increase serum potassium. Patients should be advised to report to their physician any possible symptoms of hyperkalemia such as weakness, listlessness, confusion, tingling of the extremities, or feelings of heaviness in the legs.