potassium-bicarbonate and Eplerenone Interactions

Interactions between potassium-bicarbonate(potassium bicarbonate) and Eplerenone (eplerenone)

potassium bicarbonate and eplerenone (Major Drug-Drug)

CONTRAINDICATED: The principal risk of eplerenone is hyperkalemia. Coadministration with potassium salts or potassium-sparing diuretics may increase this risk due to additive pharmacodynamic effects.

MANAGEMENT: Given the potential for serious, sometimes fatal cardiac arrhythmias associated with hyperkalemia, the use of eplerenone with potassium salts or potassium-sparing diuretics is considered contraindicated.