Drug interactions between posaconazole and Xanax
| Results for the following 2 drugs: |
|---|
| posaconazole |
| Xanax (alprazolam) |
Interactions between your selected drugs
alprazolam ↔ posaconazole
Applies to:Xanax (alprazolam) and posaconazole
ADJUST DOSE: Coadministration with posaconazole may significantly increase the plasma concentrations and pharmacologic effects of benzodiazepines that are primarily metabolized by CYP450 3A4. The mechanism is increased bioavailability and/or decreased clearance due to inhibition of intestinal and hepatic CYP450 3A4 by posaconazole. According to product labeling, pretreatment with posaconazole (200 mg tablets once a day for 10 days) increased the systemic exposure (AUC) of a single 0.05 mg/kg intravenous dose of midazolam by 83%. A greater effect is expected with oral midazolam. The interaction is subject to a high degree of interpatient variability.
MANAGEMENT: The benzodiazepine dose may require reduction during concomitant administration with posaconazole. Monitoring for increased benzodiazepine effects is recommended, and the dosage adjusted as necessary. Alternatively, benzodiazepines that are not metabolized by CYP450 3A4 (e.g., lorazepam, oxazepam, temazepam) may be considered in patients requiring posaconazole treatment.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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