Interactions between piperacillin and Amikin pediatric (amikacin)
piperacillin and amikacin (Moderate Drug-Drug)
ADJUST DOSING INTERVAL: Piperacillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is significant only in patients with renal failure or if the agents are mixed in the same IV container or line. Lower serum aminoglycoside levels may be seen, and dosage adjustments may be necessary.
MANAGEMENT: Piperacillin and aminoglycosides should be administered separately during combined therapy.
