Drug interactions between phenytoin and Prilosec
Results for the following 2 drugs: |
|
|---|---|
| phenytoin | |
| Prilosec (omeprazole) | |
Interactions between your selected drugs
phenytoin ⇔ omeprazole
Applies to: phenytoin and Prilosec (omeprazole)
MONITOR: Omeprazole may increase phenytoin serum concentrations and the risk of toxicity. The probable mechanism is inhibition of CYP450 2C hepatic metabolism. Omeprazole may interact in a similar manner with other hydantoins. The clinical significance is unknown; however, higher omeprazole doses (more than 40 mg/day) may be more likely to interact.
MANAGEMENT: Clinical and laboratory monitoring for altered phenytoin effects is recommended. Patients should be advised to notify their physician if they experience symptoms of toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia).
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