Drug interactions between Phenytoin Sodium, Prompt and tolbutamide
Results for the following 2 drugs: |
|
|---|---|
| Phenytoin Sodium, Prompt (phenytoin) | |
| tolbutamide | |
Interactions between your selected drugs
phenytoin ⇔ tolbutamide
Applies to: Phenytoin Sodium, Prompt (phenytoin) and tolbutamide
MONITOR: The coadministration with phenytoin may diminish the hypoglycemic effect of sulfonylureas. Phenytoin has been reported to cause hyperglycemia, hypoinsulinemia and glucose intolerance, thus it may interfere with blood glucose control. Conversely, some sulfonylureas may enhance the plasma concentrations and pharmacologic effects of phenytoin by competitive inhibition of its metabolism by CYP450 2C9 and/or 2C19 isoenzymes. Phenytoin intoxication has been reported during coadministration with tolbutamide specifically.
MANAGEMENT: Consideration should be given to more closely monitoring blood glucose and phenytoin levels during coadministration with sulfonylureas. Patients should be advised to notify their physician if loss of glycemic control occurs or if they experience symptoms of possible phenytoin toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, and ataxia.
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