Interactions between phenylephrine and Apraclonidine ophthalmic (apraclonidine ophthalmic)
phenylephrine and apraclonidine ophthalmic (Moderate Drug-Drug)
MONITOR: Tricyclic antidepressants and sympathomimetic agents may theoretically inhibit the effect of apraclonidine ophthalmic on intraocular pressure. Clinical data have not been reported; however, the hypotensive effects of clonidine, a related alpha-2 adrenergic agonist, have been reduced by tricyclic agents. In addition, potentiation of CNS depression (e.g., drowsiness, dizziness) may occur with the tricyclic antidepressants.
MANAGEMENT: Monitoring for altered efficacy and safety is recommended during concomitant administration.
