phenylephrine and Aldomet Interactions

Interactions between phenylephrine and Aldomet (methyldopa)

methyldopa and phenylephrine (Moderate Drug-Drug)

MONITOR: Limited data suggest that methyldopa and other sympatholytics may increase or prolong the pressor effect of sympathomimetics. Hypertension may result. Data exist for phenylpropanolamine and norepinephrine.

MANAGEMENT: If these drugs must be coadministered, blood pressure should be closely monitored. Discontinuation of the sympathomimetic may be necessary if hypertension develops.