phenylephrine and Akbeta Interactions

Interactions between phenylephrine and Akbeta (levobunolol ophthalmic)

phenylephrine and levobunolol ophthalmic (Moderate Drug-Drug)

MONITOR: Limited evidence suggests that propranolol or other nonselective beta-blockers may lead to an acute hypertensive episode when used in combination with phenylephrine. Beta blockers may enhance the pressor response to phenylephrine by blocking its beta-agonist activity. This may occur with ophthalmic or intravenous , but not intranasal dosage forms of phenylephrine.

MANAGEMENT: The clinician may consider monitoring blood pressure more closely if these drugs are coadministered. The use of cardioselective beta-blockers (e.g., acebutolol, atenolol, metoprolol, bisoprolol, betaxolol) may minimize this interaction.