Drug interactions between phenobarbital and Topamax
Results for the following 2 drugs: |
|
|---|---|
| phenobarbital | |
| Topamax (topiramate) | |
Interactions between your selected drugs
phenobarbital ⇔ topiramate
Applies to: phenobarbital and Topamax (topiramate)
The effect of coadministration of topiramate with either phenobarbital or primidone has not been fully evaluated. The coadministration of topiramate with other antiepileptic drugs, such as phenytoin, valproic acid and carbamazepine has led to alterations in plasma concentrations of one or both drugs. One study has demonstrated that there is less than a 10% change in plasma concentrations of phenobarbital or primidone when coadministered with topiramate. It is expected that topiramate levels would decrease. Use caution if phenobarbital or primidone are coadministered with topiramate, and adjust dosages if needed.
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