Drug interactions between Phenergan and Phillips' Milk of Magnesia
Results for the following 2 drugs: |
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|---|---|
| Phenergan (promethazine) | |
| Phillips' Milk of Magnesia (magnesium hydroxide) | |
Interactions between your selected drugs
promethazine ⇔ magnesium hydroxide
Applies to: Phenergan (promethazine) and Phillips' Milk of Magnesia (magnesium hydroxide)
Coadministration with aluminum- or magnesium-containing antacids may decrease the serum concentrations of orally administered phenothiazines. The proposed mechanism is antacid adsorption resulting in reduced phenothiazine bioavailability. The interaction has been reported for chlorpromazine but may occur with other phenothiazines. In a study of ten patients treated with chlorpromazine, 30 mL of an antacid containing aluminum and magnesium hydroxide reduced the urinary excretion of chlorpromazine by 10% to 45%. In another study with six psychiatric patients, coadministration of chlorpromazine oral suspension with 30 mL of an antacid containing aluminum hydroxide and magnesium trisilicate resulted in a 20% reduction in serum chlorpromazine level two hours later. The clinical significance is unknown. Psychiatric relapse occurred in a chlorpromazine-treated patient following the addition of antacid therapy according to a single case report. Separating the times of administration by 2 to 3 hours may help if an interaction is suspected.
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