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Drug Interactions between Persantine IV and regadenoson

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

dipyridamole regadenoson

Applies to: Persantine IV (dipyridamole) and regadenoson

Using dipyridamole together with regadenoson may increase the effects of regadenoson. Contact your doctor if you experience decreased blood pressure and heart rate, heart block, arrhythmias, or any other cardiovascular effects. If possible, dipyridamole should be withheld for at least two days prior to administration of regadenoson for myocardial perfusion imaging. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

dipyridamole food

Applies to: Persantine IV (dipyridamole)

Caffeine may interfere with the effects of dipyridamole in dilating the arteries. You should avoid caffeine-containing products for at least 24 hours before an imaging procedure involving dipyridamole given by injection. However, no special precaution is necessary if you are taking dipyridamole orally for maintenance.

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Moderate

regadenoson food

Applies to: regadenoson

Caffeine may interfere with the effects of regadenoson. You should avoid caffeine-containing products for at least 12 hours before an imaging procedure involving regadenoson.

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Moderate

dipyridamole food

Applies to: Persantine IV (dipyridamole)

Ask your doctor before using dipyridamole together with caffeine. Using these medications together can decrease the effects of dipyridamole. It is recommended that caffeine including caffeine be avoided for 12 to 24 hours before dipyridamole administration. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Cardiac stressing agents

Therapeutic duplication

The recommended maximum number of medicines in the 'cardiac stressing agents' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'cardiac stressing agents' category:

  • Persantine IV (dipyridamole)
  • regadenoson

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.