periostat and Methoxyflurane Interactions

Interactions between periostat(doxycycline) and Methoxyflurane (methoxyflurane)

doxycycline and methoxyflurane (Major Drug-Drug)

GENERALLY AVOID: Coadministration of tetracycline or oxytetracycline with methoxyflurane has enhanced renal toxicity. Fatalities have been reported. The mechanism is not known.

MANAGEMENT: This combination should be avoided if possible.