periostat and Amnesteem Interactions

Interactions between periostat(doxycycline) and Amnesteem (isotretinoin)

doxycycline and isotretinoin (Major Drug-Drug)

CONTRAINDICATED: The use of vitamin A or related compounds (i.e., retinoids) with tetracyclines may increase the risk of pseudotumor cerebri, or benign intracranial hypertension. These agents individually have been associated with the development of pseudotumor cerebri and may have additive effects during coadministration. Specific reported cases of the potential interaction have involved the use of isotretinoin or vitamin A in combination with tetracyclines.

MANAGEMENT: In general, vitamin A and retinoids should not be used in combination with tetracyclines. The product labeling for acitretin states that use with tetracyclines is contraindicated. Patients treated with a retinoid or a tetracycline should be advised to discontinue the medication and notify their physician immediately if they develop early symptoms of pseudotumor cerebri such as headache, nausea, vomiting, visual disturbances, and papilledema.