periostat and Aminophylline extended release Interactions

Interactions between periostat(doxycycline) and Aminophylline extended release (aminophylline)

doxycycline and aminophylline (Moderate Drug-Drug)

MONITOR: Coadministration of a tetracycline may decrease theophylline plasma clearance and increase theophylline levels. The mechanism is unknown. Data are available for minocycline, tetracycline, and doxycycline, but are conflicting in some cases. This interaction appears to be more problematic if a tetracycline is administered for more than five days. Patients with chronic obstructive pulmonary disease, congestive heart failure, or cirrhosis may have slower theophylline clearance rates; therefore, they may be at greater risk of developing theophylline toxicity.

MANAGEMENT: If these drugs are given concurrently, close clinical and laboratory monitoring of response and tolerance is recommended. Patients should be advised to notify their physician if they experience any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or irregular heartbeats. It may be necessary to reduce theophylline dosage.