pentasa and Anisindione Interactions

Interactions between pentasa(mesalamine) and Anisindione (anisindione)

anisindione and mesalamine (Moderate Drug-Drug)

MONITOR: A case has been reported of a likely interaction between warfarin and mesalamine resulting in failure to attain the hypoprothrombinemic effect of warfarin. The mechanism of this interaction is unknown. The clinician who reported this interaction speculated that mesalamine may have complexed with warfarin, preventing warfarin's intestinal absorption or metabolism. Whether rectally administered mesalamine may interfere with absorption is unclear. Data on other oral anticoagulants are lacking.

MANAGEMENT: Until more information is available, clinicians should closely monitor prothrombin time if an anticoagulant and mesalamine are administered concurrently. Patients should be advised to promptly report any signs of blood clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).