Interactions between paliperidone and Levomethadyl acetate (levomethadyl acetate)
levomethadyl acetate and paliperidone (Major Drug-Drug)
CONTRAINDICATED: Levomethadyl acetate may cause dose-related prolongation of the QT interval. Coadministration with other agents that can prolong the QT interval may result in elevated risk of ventricular arrhythmias, including ventricular tachycardia and torsade de pointes, because of additive arrhythmogenic potential related to their effects on cardiac conduction. High dosages of levomethadyl acetate alone have been associated with QT interval prolongation and torsade de pointes.
MANAGEMENT: The concurrent use of levomethadyl acetate with other medications that can prolong the QT interval is considered contraindicated.
