octreotide and Calan Interactions

Interactions between octreotide and Calan (verapamil)

verapamil and octreotide (Moderate Drug-Drug)

MONITOR: Somatostatin analogs (e.g., octreotide, lanreotide) can decrease heart rate and may potentiate the bradycardic effects of drugs like beta-blockers or calcium channel blockers. Octreotide has commonly been associated with bradycardia (less than 50 bpm), conduction abnormalities, and arrhythmias in acromegalic patients. Occasional cases of sinus bradycardia and ventricular tachycardia have also been reported with lanreotide.

MANAGEMENT: Caution is advised if somatostatin analogs are prescribed with a beta-blocker (including ophthalmic formulations) or calcium channel blocker. Heart rate and blood pressure should be monitored, and the beta-blocker or calcium channel blocker dosage adjusted as necessary.