nuvigil and Aminoglutethimide Interactions

Interactions between nuvigil(armodafinil) and Aminoglutethimide (aminoglutethimide)

aminoglutethimide and armodafinil (Moderate Drug-Drug)

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of modafinil (the racemate) and armodafinil (the R-enantiomer), which are both partially metabolized by the isoenzyme.

MANAGEMENT: Pharmacologic response to modafinil or armodafinil should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy. Dose adjustments may be required if an interaction is suspected.