Drug interactions between Norditropin Nordiflex and Toviaz
| Results for the following 2 drugs: |
|---|
| Norditropin Nordiflex (somatropin) |
| Toviaz (fesoterodine) |
Interactions between your selected drugs
somatropin ↔ fesoterodine
Applies to:Norditropin Nordiflex (somatropin) and Toviaz (fesoterodine)
MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of fesoterodine's active metabolite, 5-hydroxymethyl tolterodine, which is partially metabolized by the isoenzyme. Following induction of CYP450 3A4 with rifampin 600 mg once a day, 5-hydroxymethyl tolterodine peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately 70% and 75%, respectively, after oral administration of fesoterodine 8 mg. The effects of less potent CYP450 3A4 inducers were not examined.
MANAGEMENT: No dosing adjustments are recommended when fesoterodine is used in combination with CYP450 3A4 inducers. However, the possibility of diminished therapeutic effects should be considered.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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