Drug interactions between Nexium and rifampin
| Results for the following 2 drugs: |
|---|
| Nexium (esomeprazole) |
| rifampin |
Interactions between your selected drugs
rifampin ↔ esomeprazole
Applies to:rifampin and Nexium (esomeprazole)
GENERALLY AVOID: Coadministration with potent inducers of CYP450 2C19 and/or 3A4 may significantly decrease the plasma concentrations of omeprazole, which is primarily metabolized by these isoenzymes. In a study consisting of 12 healthy male subjects, administration of omeprazole in combination with St John's wort (300 mg three times daily for 14 days) decreased omeprazole peak plasma concentration (Cmax) and systemic exposure (AUC) in CYP450 2C19 poor metabolizers by 37.5% and 37.9%, respectively, and in extensive metabolizers by 49.6 % and 43.9%, respectively. The interaction is likely to also occur with esomeprazole, an enantiomer of omeprazole.
MANAGEMENT: The concomitant use of omeprazole or esomeprazole with St. John's wort or rifampin should generally be avoided.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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