Drug interactions between nateglinide and Singulair
Results for the following 2 drugs: |
|
|---|---|
| nateglinide | |
| Singulair (montelukast) | |
Interactions between your selected drugs
montelukast ⇔ nateglinide
Applies to: Singulair (montelukast) and nateglinide
MONITOR: The coadministration of nateglinide and drugs that are substrates of the CYP450 2C9 enzymatic pathway may result in elevated plasma concentrations of those drugs. The mechanism is decreased clearance due to inhibition of CYP450 2C9 activity by nateglinide.
MANAGEMENT: Caution is advised if nateglinide must be used concomitantly with medications that undergo metabolism by CYP450 2C9, particularly those with a narrow therapeutic range. A lower initial dosage, as well as clinical and laboratory monitoring, may be appropriate for some drugs.
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