naltrexone and Actiq Interactions

Interactions between naltrexone and Actiq (fentanyl)

fentanyl and naltrexone (Moderate Drug-Drug)

ADJUST DOSE: Patients taking naltrexone may not benefit from opioid medications, due to opioid receptor antagonism by naltrexone.

MANAGEMENT: If an emergency situation requires that opioid analgesia be administered to a patient who has received naltrexone, the amount of opioid required may be greater than usual, and the resulting respiratory depression may be deeper and more prolonged. Patients should be closely monitored for altered efficacy and safety.