nafcillin and Cyclosporine Interactions

Interactions between nafcillin and Cyclosporine (cycloSPORINE)

nafcillin and cycloSPORINE (Moderate Drug-Drug)

MONITOR: Nafcillin may decrease serum cyclosporine concentrations by an unknown mechanism and may result in subtherapeutic cyclosporine levels. The risk of rejection may be increased in transplant patients.

MANAGEMENT: Given the risk of organ rejection associated with inadequate immunosuppressant levels, caution is advised if cyclosporine must be coadministered with nafcillin. Cyclosporine blood levels should be closely monitored and the dosage adjusted accordingly.