nadolol and Brethine Interactions

Interactions between nadolol and Brethine (terbutaline)

nadolol and terbutaline (Major Drug-Drug)

GENERALLY AVOID: Beta blockers may antagonize the effects of bronchodilator beta-adrenergic agonists, which may result in life-threatening bronchospasm. The mechanism is increased airway resistance and inhibition of beta-agonist-induced bronchodilation due to beta-2-adrenergic blockade. Ophthalmically applied beta blockers undergo some systemic absorption and may also interact. Propranolol has been used in the treatment of albuterol overdose.

MANAGEMENT: This combination should generally be avoided. If no alternative exists, small doses of a B-1 selective beta-blocker (e.g., acebutolol, atenolol, betaxolol, bisoprolol, or metoprolol) may be preferable; however, extreme caution is advised and patients' respiratory status should be closely monitored. Non-selective beta-blockers are generally considered contraindicated in patients with obstructive airways disease.