Drug interactions between Mutamycin and tamoxifen
Results for the following 2 drugs: |
|
|---|---|
| Mutamycin (mitomycin) | |
| tamoxifen | |
Interactions between your selected drugs
mitomycin ⇔ tamoxifen
Applies to: Mutamycin (mitomycin) and tamoxifen
GENERALLY AVOID: Tamoxifen significantly increases the risk of microangiopathic hemolytic uremic syndrome (HUS) associated with mitomycin C. HUS can be fatal in up to 50% of affected patients. The mechanism of this interaction is not known, but may involve a combination of subclinical endothelial damage induced by mitomycin C and a thrombotic effect on platelets caused by tamoxifen. MANAGEMENT: Some experts advise that tamoxifen should be avoided during or immediately after mitomycin C therapy unless the patient is carefully monitored with frequent and regular CBCs as well as serum BUN and creatinine measurements.
See also...
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2009 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
