Drug interactions between Mirapex and Sinemet
| Results for the following 2 drugs: |
|---|
| Mirapex (pramipexole) |
| Sinemet (carbidopa/levodopa) |
Interactions between your selected drugs
levodopa ↔ pramipexole
Applies to:Sinemet (carbidopa/levodopa) and Mirapex (pramipexole)
ADJUST DOSE: Pramipexole may potentiate the dopaminergic side effects of levodopa, resulting in development or exacerbation of dyskinesia. In clinical trials, other adverse effects such as hallucinations, orthostatic hypotension, extrapyramidal syndrome, insomnia, and dizziness were also increased in patients with advanced Parkinson's disease treated with the combination compared to levodopa alone. Pharmacokinetically, pramipexole has been reported to increase the serum peak levels (Cmax) of levodopa by 40% and decrease the time to reach peak levels (Tmax) from 2.5 to 0.5 hours without affecting the overall extent of absorption. However, a study consisting of 26 patients with Parkinson's disease stabilized on levodopa/carbidopa therapy found no significant changes in levodopa pharmacokinetics following the addition of pramipexole for 7 weeks.
MANAGEMENT: A reduction of levodopa dosage should be considered during coadministration with pramipexole. In a controlled study in advanced Parkinson's disease, the dosage of levodopa was reduced by an average of 27% from baseline.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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