Drug interactions between Miradon and tigecycline
| Results for the following 2 drugs: |
|---|
| Miradon (anisindione) |
| tigecycline |
Interactions between your selected drugs
anisindione ↔ tigecycline
Applies to:Miradon (anisindione) and tigecycline
MONITOR: Coadministration with tigecycline may increase the plasma concentrations of warfarin. The mechanism of interaction has not been described, although it seems to affect the biologically less active R(+) enantiomer of warfarin more than the S(-) enantiomer. In healthy subjects, coadministration of tigecycline (100 mg followed by 50 mg every 12 hours) and warfarin (25 mg single oral dose) resulted in a decrease in clearance of R(+) and S(-) warfarin by 40% and 23%, an increase in the peak plasma concentration (Cmax) by 38% and 43%, and an increase in the systemic exposure (AUC) by 68% and 29%, respectively. However, the hypoprothrombinemic effects of warfarin were not affected as measured by the INR. Warfarin did not alter the pharmacokinetics of tigecycline.
MANAGEMENT: Given the potential for interaction and the high degree of interpatient variability with respect to warfarin metabolism, patients should be closely monitored during concomitant therapy with tigecycline. The INR should be checked frequently and warfarin dosage adjusted accordingly, particularly following initiation or discontinuation of tigecycline in patients who are stabilized on their warfarin regimen. The same precaution may be applicable during therapy with other oral anticoagulants, although clinical data are lacking. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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