Drug interactions between Miradon and Ticlid
| Results for the following 2 drugs: |
|---|
| Miradon (anisindione) |
| Ticlid (ticlopidine) |
Interactions between your selected drugs
ticlopidine ↔ anisindione
Applies to:Ticlid (ticlopidine) and Miradon (anisindione)
MONITOR: Although therapy with oral anticoagulants and ticlopidine may overlap in clinical practice, the potential for additive pharmacodynamic effects and increased risk of bleeding, especially gastrointestinal bleeding, should be considered. The combination of warfarin and ticlopidine has also been associated with rare cases of cholestatic hepatitis. In addition, ticlopidine may inhibit the metabolism of R-warfarin by an unknown mechanism. Increases in R-warfarin concentrations have been reported during concomitant therapy; however, there were no significant changes in INR.
MANAGEMENT: The manufacturer recommends discontinuation of any anticoagulants before initiating ticlopidine therapy. If concomitant use cannot be avoided, patients should be closely monitored for signs of bleeding and the anticoagulant dosage should be adjusted as appropriate to maintain therapeutic aPTT/INR values. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bruising, red or brown urine, or red or black stools.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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