Drug interactions between Miradon and Prozac
| Results for the following 2 drugs: |
|---|
| Miradon (anisindione) |
| Prozac (fluoxetine) |
Interactions between your selected drugs
fluoxetine ↔ anisindione
Applies to:Prozac (fluoxetine) and Miradon (anisindione)
MONITOR: Several case reports, including one report of cerebral hemorrhage, suggest that fluoxetine may increase the anticoagulant effects of warfarin. Postulated mechanisms include displacement of warfarin from plasma protein-binding sites, inhibition of the CYP450 2C9 hepatic metabolism of warfarin by fluoxetine, and direct inhibitory effect of fluoxetine on hemostasis. Animal studies have also suggested that fluoxetine (given in very high doses) may increase prothrombin time in animals treated with warfarin. Two small studies of human volunteers, however, found no alteration in the prothrombin time in individuals treated with fluoxetine and warfarin. It is not known if other oral anticoagulants interact with fluoxetine in a similar manner.
MANAGEMENT: Close clinical and laboratory monitoring for altered anticoagulant effect is recommended if oral anticoagulants and fluoxetine must be used together. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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