Drug interactions between Miradon and Phenytek
| Results for the following 2 drugs: |
|---|
| Miradon (anisindione) |
| Phenytek (phenytoin) |
Interactions between your selected drugs
phenytoin ↔ anisindione
Applies to:Phenytek (phenytoin) and Miradon (anisindione)
MONITOR: Some oral anticoagulants have been reported to increase phenytoin half-life and serum concentrations, possibly by inhibiting CYP450 metabolism. The addition of phenytoin to warfarin therapy has initially increased prothrombin time, but thereafter reduced anticoagulant effects. The mechanism is not known, but may be due to initial CYP450 metabolic inhibition, followed by isoenzyme induction. Data have been conflicting.
MANAGEMENT: Phenytoin serum concentrations and INR/PT should be monitored in patients receiving this combination and whenever the dosage is changed or discontinued. Patients should be advised to promptly report any signs of bleeding (e.g., pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, nosebleeds, bleeding of gums from brushing, red or brown urine, or red or black stools) or hydantoin toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia) to their physician.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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