Drug interactions between Miradon and Myorisan
| Results for the following 2 drugs: |
|---|
| Miradon (anisindione) |
| Myorisan (isotretinoin) |
Interactions between your selected drugs
anisindione ↔ isotretinoin
Applies to:Miradon (anisindione) and Myorisan (isotretinoin)
MONITOR: Limited data suggest that isotretinoin may reduce the hypoprothrombinemic effect of warfarin. The mechanism of interaction is unknown. A case report describes a 61-year-old patient stabilized on warfarin 2.5 mg/day for 2 to 3 years who experienced a decreased INR following initiation of cefpodoxime proxetil (200 mg orally twice a day) and isotretinoin (30 mg orally daily) for a facial eruption due to Klebsiella infection. An increase in the warfarin dosage to 3.75 mg/day was necessary to maintain his INR within therapeutic range. The INR remained stable at the new dosage after completion of cefpodoxime therapy but increased when isotretinoin was discontinued after 40 days. Warfarin dosage was subsequently reduced to the previous level.
MANAGEMENT: Until further information is available, INR should be monitored more closely whenever isotretinoin is added to or withdrawn from therapy, and the warfarin dosage adjusted as necessary. The same precaution may be applicable during therapy with other oral anticoagulants, although clinical data are lacking.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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