minocycline-hydrochloride and Methotrexate sodium preservative free Interactions

Interactions between minocycline-hydrochloride(minocycline) and Methotrexate sodium preservative free (methotrexate)

methotrexate and minocycline (Major Drug-Drug)

GENERALLY AVOID: Concomitant use of tetracyclines may elevate serum methotrexate concentrations. The mechanism may involve displacement of methotrexate from its binding to plasma proteins. Individual cases of methotrexate toxicity have been reported with doxycycline and tetracycline.

MANAGEMENT: Concomitant use of tetracyclines should be avoided in patients on high-dose methotrexate regimens. If broad-spectrum antibiotic coverage is needed during high-dose methotrexate therapy, the use of an alternate anti-infective is recommended. If these drugs must be used together, close monitoring for evidence of serious methotrexate toxicity is recommended.