Methadone Drug Interactions

methadone is known to interact with the following drugs:

Click on a link below to view Drug-Drug Interactions with methadone.

Major Interaction Major Interactions
abarelix, Accuneb, Adapin, Adeno-jec, Adenocard, Adenoscan, adenosine, adenosine monophosphate, adenosine triphosphate, Adgan, Adriamycin, Adriamycin RDF, Airet, albuterol, albuterol extended release, alfuzosin, alfuzosin extended release, Aloxi, Alupent, alvimopan, amiodarone, amitriptyline, amoxapine, Anafranil, Anergan 50, Antinaus 50, Anzemet, APO-Go, APO-Go Pen, Apokyn, apomorphine, Aralen Hydrochloride, Aralen Phosphate, arsenic trioxide, Asendin, astemizole, Atapryl, Avelox, Avelox I.V., Aventyl HCl, Azilect, azithromycin, Azithromycin 3 Day Dose Pack, Azithromycin 5 Day Dose Pack, azithromycin extended release, bepridil, Betapace, Betapace AF, Betapace AF(obsolete), Biaxin, Biaxin XL, Biaxin XL-Pak, Brethaire, Brethine, Bricanyl, Budeprion SR, Budeprion XL, buPROPion, buPROPion 24 hour extended release, buPROPion extended release, Carbex, Cardioquin, Cerubidine, Chem Mart Tamoxifen, Chem Mart Tramadol, chloroquine, chloroquine hydrochloride, chloroquine phosphate, chlorproMAZINE, chlorproMAZINE extended release, cisapride, clarithromycin, clarithromycin extended release, clomiPRAMINE, Compazine, Compazine Spansule, Compro, Cordarone, Cordarone I.V., Corvert, Darvon, Darvon-N, dasatinib, DAUNOrubicin, DAUNOrubicin liposomal, Daunoxome, Definity, desipramine, disopyramide, disopyramide extended release, dofetilide, dolasetron, doxepin, doxepin topical, Doxil, DOXOrubicin, DOXOrubicin liposomal, Dromadol SR, Dromadol XL, droperidol, E-Mycin, E.E.S. Granules, E.E.S.-200, E.E.S.-400, E.E.S.-400 Filmtab, Elavil, Eldepryl, Ellence, Emblon, Emsam, Endep, Entereg, epirubicin, Ery-Tab, Eryc, EryPed, EryPed 200, EryPed 400, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, Erythrocot, erythromycin, erythromycin base, erythromycin estolate, erythromycin ethylsuccinate, erythromycin lactobionate, erythromycin stearate, Factive, FK506, flecainide, Floxin, Floxin I.V., Fluothane, fluphenazine, fluphenazine decanoate, fluphenazine enanthate, fluphenazine hydrochloride, furazolidone, Furoxone, gatifloxacin, gemifloxacin, Genox, GenRx Tamoxifen, GenRx Tramadol, Geodon, GHB, grepafloxacin, Haldol, Haldol Decanoate, Halfan, halofantrine, haloperidol, haloperidol decanoate, halothane, Hismanal, ibutilide, Idamycin PFS, idarubicin, Ilosone, Ilotycin Gluceptate, imipramine, imipramine pamoate, Inapsine, Invega, iohexol, iopamidol, Iopamidol-370, isocarboxazid, isoproterenol, Isovue-128, Isovue-200, Isovue-250, Isovue-300, Isovue-370, Isovue-M-200, Isovue-M-300, Isuprel HCl, Isuprel Mistometer, Jumex, Ketek, Ketek Pak, lapatinib, Larapam SR, Largon, Lariam, Levaquin, Levaquin Leva-Pak, Levitra, levofloxacin, levomethadyl acetate, Levoprome, lomefloxacin, Lorelco, Ludiomil, maprotiline, Marplan, Matulane, Maxaquin, Medihaler-Iso, mefloquine, Mellaril, Mellaril-S, mesoridazine, Metaprel, metaproterenol, methdilazine, methotrimeprazine, metrizamide, moxifloxacin, MY-E, My-O-Den, Myelo-Kit, naloxone, Narcan, Nardil, Nebupent, nilotinib, Nolvadex, Nolvadex D, norfloxacin, Noroxin, Norpace, Norpace CR, Norpramin, nortriptyline, ofloxacin, Omnipaque 140, Omnipaque 180, Omnipaque 180 Redi-Unit, Omnipaque 210, Omnipaque 240, Omnipaque 240 Redi-Unit, Omnipaque 300, Omnipaque 350, Omnipaque Flexipak, ondansetron, Optison, Orap, Orlaam, Ormazine, Pacerone, paliperidone, palonosetron, Pamelor, Parnate, PCE Dispertab, Pentam 300, pentamidine, Pentazine, perflutren, Permitil, perphenazine, Pharmorubicin PFS, Pharmorubicin RDF, Phenadoz, Phenazine 50, phenelzine, Phenergan, Phenergan Fortis, Phenoject-50, pimozide, Pitressin, Plenaxis, PP-Cap, Pro-Med, ProAir HFA, probucol, procainamide, procainamide 12 hour extended release, procainamide extended release, Procan SR, Procanbid, procarbazine, prochlorperazine, prochlorperazine extended release, Procot, Prograf, Prolixin, Prolixin Decanoate, Prolixin Enanthate, Promacot, promazine, promethazine, Promethegan, Pronestyl, Pronestyl-SR, propafenone, propafenone extended release, propiomazine, propoxyphene, propoxyphene hydrochloride, propoxyphene napsylate, Propulsid, Prorex, protriptyline, Proventil, Proventil HFA, Proventil Repetabs, Prudoxin, QM-260, Qualaquin, Quin-G, Quin-Release, Quinaglute Dura-Tabs, Quinidex Extentabs, quinidine, quinidine extended release, quinine, Quinora, Ranexa, ranolazine, rasagiline, Raxar, Respirol, Risperdal, Risperdal Consta, Risperdal M-Tab, risperidone, ritodrine, Robimycin, Rythmol, Rythmol SR, selegiline, Selgene, Serentil, Sinequan, sodium biphosphate, sodium oxybate, Soltamox, Sorine, sotalol, Sotalol Hydrochloride AF, Sotalol Hydrochloride AF(obsolete), sparfloxacin, Sparine, Sprycel, Stelazine, Surmontil, Tacaryl, tacrolimus, Tambocor, Tamofen, Tamofen(obsolete), Tamone, Tamosin, Tamoxen, tamoxifen, Tamoxifen Hexal, Tasigna, telithromycin, Temaril, Tequin, Tequin Teqpaq, terbutaline, terfenadine, Terry White Chemists Tamoxifen, Terry White Chemists Tramadol, thioridazine, Thorazine, Tikosyn, tizanidine, Tofranil, Tofranil-PM, traMADOL, traMADOL extended release, Tramahexal, Tramahexal SR, Tramake, Tramake Insts, Tramal, Tramal SR, Tramedo, tranylcypromine, trifluoperazine, triflupromazine, Trilafon, trimeprazine, trimipramine, Trisenox, Tykerb, Ultram, Ultram ER, Uprima, Uroxatral, V-Gan-25, V-Gan-50, Vanatrip, vardenafil, Vascor, vasopressin, Ventolin, Ventolin HFA, Ventolin Nebules, Ventolin Rotacaps, VFEND, Vivactil, Volmax, voriconazole, vorinostat, VoSpire ER, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Xyrem, Yutopar, Z-Pak, Zagam, Zagam Respipac, Zamadol, Zamadol 24hr, Zamadol Melt, Zamadol SR, Zanaflex, Zelapar, ziprasidone, Zithromax, Zithromax IV, Zithromax TRI-PAK, Zithromax Z-Pak, Zmax, Zofran, Zofran ODT, Zolinza, Zonalon, Zyban, Zyban Advantage Pack, Zydol, Zydol SR, Zydol XL

Moderate Interaction Moderate Interactions
40 Winks, A-Spas S/L, abacavir, Abilify, Abilify Discmelt, Accolate, Accupril, acebutolol, Aceon, acetylcarbromal, Actiq, activated attapulgite, Adalat, Adalat CC, Adrenocot, Adrenocot L.A., Afeditab CR, Agenerase, AHist, Akineton HCl, alcohol, alcohol, ethyl, Aldactone, Aler-Dryl, Aler-Tab, Alfenta, alfentanil, All Day Allergy, Aller-Chlor, Allergia-C, Allerhist-1, Allermax, Alphagan, Alphagan P, alprazolam, alprazolam extended release, Altace, Altaryl, Ambien, Ambien CR, amiloride, amlodipine, amobarbital, amprenavir, Amrix, amyl nitrite, Amytal Sodium, Anaspaz, Antiflex, Antivert, Anturane, apraclonidine ophthalmic, aprepitant, Apresoline, Aquachloral Supprettes, Aquazide H, Arfonad, arformoterol, aripiprazole, Artane, Astelin, Astramorph PF, Atacand, Atarax, atenolol, Ativan, atomoxetine, Atreza, AtroPen, atropine, attapulgite, Avapro, Avinza, azatadine, azelastine nasal, AZT, B-Vex, baclofen, Banaril, Banflex, Banophen, Beldin, Belix, belladonna, Belladonna Tincture, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Child Dye Free, Benadryl Childrens Allergy Fastmelt, Benadryl DF, Benadryl Dye Free Allergy, Benadryl Ultratab, Benahist-10, Benahist-50, bendroflumethiazide, Benicar, Benoject-50, Bentyl, Benzacot, benzthiazide, benztropine, betaxolol, Betimol, bexarotene, Bidhist, biperiden, Bismarex, Bismatrol, Bismatrol Maximum Strength, bismuth subgallate, bismuth subnitrate, bismuth subsalicylate, bisoprolol, bitolterol, Blocadren, Bonine, bosentan, Brevibloc, Brevital Sodium, brimonidine ophthalmic, Bromaphen, bromocriptine, bromodiphenhydramine, brompheniramine, brompheniramine extended release, Bronkometer, Brovana, BroveX, BroveX CT, Bubbli-Pred, bumetanide, Bumex, Buprenex, buprenorphine, Busodium, BuSpar, BuSpar Dividose, busPIRone, butabarbital, butalbital, Butisol Sodium, butorphanol, butorphanol nasal, Bydramine, C.P.M., Calan, Calan SR, Calm-Aid, candesartan, Cantil, Capoten, captopril, Carbacot, carbamazepine, carbamazepine extended release, Carbatrol, carbetapentane, carbinoxamine, carbinoxamine extended release, Carbinoxamine PD, Carboxine, Cardene, Cardene IV, Cardene SR, Cardizem, Cardizem CD, Cardizem LA, Cardizem Monovial, Cardizem SR, Cardura, Cardura XL, Carduran, carisoprodol, Carozide, Cartia XT, carvedilol, carvedilol extended release, Cascor, Catapres, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3, Celexa, Celontin, Cerebyx, Cesamet, cetirizine, Childrens Kaopectate, Chlo-Amine, Chlor-Al Rel, Chlor-Mal, Chlor-Phen, Chlor-Phenit, Chlor-Trimeton, Chlor-Trimeton Allergy SR, chloral hydrate, chlordiazepoxide, chlormezanone, chlorothiazide, Chlorphen, chlorphenesin, chlorpheniramine, Chlorpheniramine (Allergy), chlorpheniramine 24 hour extended release, chlorpheniramine extended release, ChlorTan, chlorthalidone, chlorzoxazone, cimetidine, Cipro, Cipro Cystitis Pack, Cipro I.V., Cipro XR, ciprofloxacin, ciprofloxacin extended release, citalopram, clemastine, clidinium, clonazepam, clonidine, clonidine topical, Clopine, clorazepate, clorazepate extended release, clotrimazole, clozapine, Clozapine Synthon, Clozaril, codeine, codeine phosphate, codeine sulfate, Codimal A, Cogentin, Compound 374, Compoz Nighttime Sleep Aid, Comtan, conivaptan, Contac 12 Hour Allergy, Cophene B, Cordron NR, Coreg, Coreg CR, Corgard, Cortastat, Cortastat 10, Cortastat LA, Cotolone, Covera-HS, Cozaar, Crixivan, cyclizine, cyclobenzaprine, cyclobenzaprine extended release, cycloSPORINE, Cymbalta, cyproheptadine, Cystospaz, Cystospaz-M, D-Vert, D.H.E. 45, Dailyhist-1, Dalalone, Dalalone D.P., Dalalone L.A., dalfopristin, Dalgan, Dalmane, danazol, Danocrine, Dantrium, Dantrium Intravenous, dantrolene, darifenacin, Dazidox, De-Sone LA, Decadron, Decadron 5-12 Pak, Decadron Phosphate, Injectable, Decadron-LA, Decaject, Decaject L.A., Dehydrated Alcohol, delavirdine, Demadex, Demadex I.V., Demerol HCl, Denzapine, Depacon, Depakene, Depakote, Depakote ER, Depakote Sprinkles, Depo-Predate (obsolete), DepoDur, Deponit, desflurane, desvenlafaxine, Desyrel, Desyrel Dividose, Dexacen-4, Dexacort Phosphate in Respihaler, Dexacort-LA, Dexacorten, dexamethasone, dexamethasone acetate, Dexamethasone Intensol, dexamethasone sodium phosphate, Dexasone, Dexasone LA, dexbrompheniramine, dexmedetomidine, Dexone, Dexone LA, Dexpak Jr. Taperpak, Dexpak Taperpak, dezocine, Di-Phen, Diamode, Diaqua, Diaqua-2, Diar-Aid, Diastat, Diastat AcuDial, Diastat Pediatric, diazepam, diazoxide, Dibenzyline, dichloralphenazone, Dicyclocot, dicyclomine, difenoxin, Diflucan, dihydrocodeine, dihydroergotamine, dihydroergotamine nasal, Dilacor XR, Dilantin, Dilantin Infatabs, Dilantin Kapseals, Dilantin-125, Dilatrate-SR, Dilaudid, Dilaudid-5, Dilaudid-HP, Diltia XT, diltiazem, diltiazem 24 hour extended release, diltiazem extended release, Diltiazem Hydrochloride CD, Diltiazem Hydrochloride SR, Diltiazem Hydrochloride XR, Diltiazem Hydrochloride XT, Dimetane, Dimetane Extentab, Dimetapp Allergy, Dimetapp Allergy Liquigel, Diovan, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, diphenhydrAMINE, diphenhydrAMINE citrate, diphenhydrAMINE tannate, Diphenmax, diphenoxylate, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Diprivan, Ditropan, Ditropan XL, Diucardin, Diuril, Diuril Sodium, divalproex sodium, divalproex sodium extended release, Dizac, Doloral, Doloral Sirop, Donnagel, Donnamar, Doral, Doxadura, doxazosin, doxazosin extended release, doxylamine, DPH, Dramamine II, Driminate II, dronabinol, duloxetine, Duraclon, Duragesic, Duragesic-100, Duragesic-12, Duragesic-25, Duragesic-50, Duragesic-75, Duramorph PF, Dynacirc, Dynacirc CR, Dyrenium, Dytan, Dytuss, Ed Chlor-Tan, Ed ChlorPed, efavirenz, Effexor, Effexor XR, Efidac-24 Chlorpheniramine, Emend, Emend 3-Day, Emend for Injection, Enablex, enalapril, enalaprilat, Endocodone, enflurane, entacapone, Epitol, eprosartan, Equanil, Equetro, Ergomar, ergotamine, escitalopram, Esidrix, Eskalith, Eskalith-CR, esmolol, estazolam, eszopiclone, ETH-Oxydose, ethanol, ethchlorvynol, ethosuximide, Ethrane, Ethyl Alcohol, etravirine, Exna, Eze D.S., Ezide, FazaClo, felbamate, Felbatol, felodipine, felodipine extended release, fentanyl, Fentora, Fexmid, flavoxate, Flexeril, Flexoject, Flexon, Flo-Pred, fluconazole, flurazepam, fluvoxamine, fluvoxamine extended release, Foradil Aerolizer, Forane, formoterol, Fortovase, fosamprenavir, fosaprepitant, fosinopril, fosphenytoin, furosemide, gabapentin, Gabarone, Gabitril, Genahist, Gengraf, Gleevec, guanethidine, halazepam, Halcion, HCTZ, Hexadrol, Hexadrol Phosphate, Histaject, Histex CT, Histex I/E, Histex PD, Histex Pd 12, Hydeltra-T.B.A., Hydeltrasol, hydrALAZINE, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hydro Par, hydrochlorothiazide, HydroDIURIL, hydroflumethiazide, Hydromorph Contin, hydromorphone, hydromorphone extended release, Hydrostat IR, hydrOXYzine, hydrOXYzine hydrochloride, hydrOXYzine pamoate, Hygroton, HyoMax FT, HyoMax SL, HyoMax SR, hyoscyamine, hyoscyamine extended release, Hyosol, Hyospaz, Hyosyne, hypericum perforatum, Hyperstat, Hyrexin, Hytrin, Hyzine, IB-Stat, imatinib, Imdur, Imodium, Imodium A-D, Imodium A-D EZ Chews, Imodium A-D New Formula, Imotil, indapamide, Inderal, Inderal LA, indinavir, Infumorph, INH, InnoPran XL, Intelence, Invirase, Ionsys, Iopidine, irbesartan, ISDN, Ismelin, ISMO, Isochron, isoetharine, isoflurane, isoniazid, Isoptin, Isoptin I.V., Isoptin SR, Isordil, Isordil Tembids, Isordil Titradose, isosorbide dinitrate, isosorbide dinitrate extended release, isosorbide mononitrate, isosorbide mononitrate extended release, isradipine, isradipine extended release, Istalol, itraconazole, J-Tan, J-Tan PD, K-Pec, K-Pek, Ka-Pec, Kadian, Kao-Paverin, Kao-Pulgite, Kao-Tin Bismuth Subsalicylate Formula, Kao-Tin(obsolete), kaolin, Kaopectate, Kaopectate Anti-Diarrheal Upset Stomach Reliever, Kaopectate Caplet, Kaopectate Caplets, Kaopectate Extra Strength, Kaopek, Kapectolin (New Formula), Kemadrin, Keppra, Kerlone, Ketalar, ketamine, ketoconazole, Key-Pred, Key-Pred SP, Klonopin, Klonopin Wafer, L-hyoscyamine, labetalol, Lamictal, Lamictal Blue, Lamictal CD, Lamictal Green, Lamictal Orange, lamotrigine, Lasix, levalbuterol, Levbid, levetiracetam, levocetirizine, LEVRIX, Levsin, Levsin SL, Levsinex SR, Lexapro, Lexiva, Librium, lindane topical, Lioresal, Lioresal Intrathecal, lisinopril, lithium, lithium carbonate, lithium carbonate extended release, lithium citrate, Lithobid, Lithonate, Lithotabs, Lo-Aqua, Lodrane 12 Hour, Lodrane 24, Lodrane XR, Loniten, loperamide, Lopressor, Loqua, lorazepam, losartan, loxapine, Loxitane, Loxitane C, Loxitane IM, Lozol, Luminal, Lunesta, Luvox, Luvox CR, Lyrica, M-Eslon, M-Oxy, M. O. S., Maalox Anti-Diarrheal, Maalox Total Stomach Relief, Maolate, Marezine, Marinol, Mavik, Maxair, Maxair Autohaler, Maximum Strength Stress, MB-TAB, Mebaral, Meclicot, meclizine, Medicort, Medidex, Medidex LA, Medivert, Meni-D, mepenzolate, meperidine, mephobarbital, meprobamate, Meridia, metaxalone, methocarbamol, methohexital, methoxyflurane, methscopolamine, methsuximide, metoclopramide, metolazone, metoprolol, metoprolol extended release, metoprolol succinate, Metoprolol Succinate ER, metoprolol tartrate, mibefradil, Micardis, miconazole, Microzide, Midamor, midazolam, Migranal, Millipred, Milontin, Miltown, Minipress, Minitran, minoxidil, Mio-Rel, Mirapex, mirtazapine, Mitran, Moban, moexipril, molindone, Monistat I.V., Monoket, Monopril, morphine, morphine 24 hour extended release, morphine extended release, Morphine IR, morphine liposomal, Morphine LP Epidural, morphine preservative-free, Morphine Rapi-Ject, Morphitec, MS, MS Contin, MS/S, MSIR, Mycelex Troche, Mykrox, Myolin, Mysoline, nabilone, nadolol, nalbuphine, naltrexone, Nasahist B, nateglinide, Naturetin-10, Naturetin-5, Navane, ND-Stat, nefazodone, nelfinavir, Nembutal, Nembutal Sodium, Neoral, Nervine, Neupro, Neurontin, nevirapine, niCARdipine, niCARdipine extended release, Nifediac CC, Nifedical XL, NIFEdipine, NIFEdipine extended release, Nightime Sleepaid, Niravam, nisoldipine, Nitrek, Nitro TD Patch-A, Nitro-Bid, Nitro-Bid IV, Nitro-Dur, Nitro-Par, Nitro-Time, Nitrocot, Nitrodisc, Nitrogard, nitroglycerin, Nitroglyn E-R, Nitrol, Nitrol Appli-Kit, Nitrolingual, Nitrong, Nitropress, nitroprusside, Nitroquick, Nitrostat, nitrous oxide, Nizoral, Nolahist, Norflex, Norflex Injectable, Normodyne, Norvasc, Norvir, Norvir Soft Gelatin, NTG, Nu-Med, Nubain, Nulev, Nydrazid, Nytol Caplet, Nytol Maximum Strength, olanzapine, olmesartan, olopatadine nasal, OMS, opium, Opium Deodorized, Optimine, Oramorph SR, Orapred, Orapred ODT, Oretic, Orfro, orphenadrine, orphenadrine extended release, Orphenate, oxazepam, oxcarbazepine, oxybutynin, oxybutynin extended release, oxycodone, oxycodone extended release, OxyContin, Oxyfast, OxyIR, Oxytrol, P-Tann, P-Tex, Palgic, Palladone, Palladone SR, Pamine, Pamine Forte, Paradione, Paraflex, Parafon Forte DSC, Paral, paraldehyde, paramethadione, Pardryl, Paregoric, Parepectolin, Parlodel, Patanase, Paxarel, PBZ, PBZ-SR, Pediapred, PediaTan, Pediatex, Pediatex 12, Pediox, Pediox-S, peginterferon alfa-2b, PegIntron, PegIntron Redipen, pegvisomant, pentazocine, Penthrane, pentobarbital, Pentothal, Peptic Relief, Pepto Diarrhea Control, Pepto-Bismol, Pepto-Bismol Maximum Strength, Percolone, Perforomist, pergolide, Periactin, perindopril, Permax, phenacemide, phenindamine, phenobarbital, phenoxybenzamine, phensuximide, phentolamine, Phenurone, phenylbutazone, phenyltoloxamine, Phenytek, phenytoin, phenytoin extended release, Phenytoin Sodium, Prompt, pindolol, Pink Bismuth, pirbuterol, Placidyl, Plendil, polythiazide, Posicor, pramipexole, prazosin, Precedex, Pred-Ject-50, Predacort 50, Predaject-50, Predalone 50, Predate-50, Predcor, Predicort RP, Predicort-50, prednisoLONE, prednisoLONE acetate, prednisoLONE sodium phosphate, prednisoLONE tebutate, pregabalin, Prelone, Pri-Cortin 50, Prialt, Priftin, Primethasone, primidone, Prinivil, Pristiq, Pro-Banthine, Procardia, Procardia XL, procyclidine, Proglycem, Prop-A-Tane, propantheline, propofol, propranolol, propranolol extended release, Proquin XR, Prosom, pyrilamine, pyrilamine extended release, Pyrlex, Q-Dryl, Q-Dryl A/F, QDALL AR, Quarzan, quazepam, Quenalin, quetiapine, quetiapine extended release, quinapril, ramipril, Rapamune, Reglan, Regurin, Relaxazone, Remeron, Remeron SolTab, remifentanil, Remular, Remular-S, Renese, Repreve, Requip, ReQuip Follow on Pack, Requip Starter Kit, ReQuip Starter Pack, Requip XL, Rescriptor, Rescudose, Restoril, Retrovir, Revatio, ReVia, Rezine, Rezulin, Rheaban Maximum Strength, Ridramin, Rifadin, Rifadin IV, rifampin, rifapentine, Rimactane, ritonavir, RMS, Robaxin, Robaxin-750, Rohist, ropinirole, ropinirole extended release,