Drug interactions between methadone and Ziagen
Results for the following 2 drugs: |
|
|---|---|
| methadone | |
| Ziagen (abacavir) | |
Interactions between your selected drugs
methadone ⇔ abacavir
Applies to: methadone and Ziagen (abacavir)
MONITOR: The concomitant administration of abacavir may modestly increase the clearance of methadone. The mechanism is unknown. In a study of eleven patients receiving oral methadone (40 mg and 90 mg daily) and abacavir (600 mg twice daily), methadone clearance increased by 22%. This change is generally clinically insignificant but a small number of patients may require a higher methadone dose.
MANAGEMENT: Pharmacologic response to methadone should be monitored more closely whenever abacavir is added to or withdrawn from therapy, and the dosage adjusted as necessary.
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