Drug interactions between methadone and Ziagen
| Results for the following 2 drugs: |
|---|
| methadone |
| Ziagen (abacavir) |
Interactions between your selected drugs
methadone ↔ abacavir
Applies to:methadone and Ziagen (abacavir)
MONITOR: The concomitant administration of abacavir may modestly increase the clearance of methadone. The mechanism is unknown. In a study of eleven patients receiving oral methadone (40 mg and 90 mg daily) and abacavir (600 mg twice daily), methadone clearance increased by 22%. This change is generally clinically insignificant but a small number of patients may require a higher methadone dose.
MANAGEMENT: Pharmacologic response to methadone should be monitored more closely whenever abacavir is added to or withdrawn from therapy, and the dosage adjusted as necessary.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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