mephobarbital and A pak laboratories paediatric analgesic paracetamol Interactions

Interactions between mephobarbital and A pak laboratories paediatric analgesic paracetamol (acetaminophen)

acetaminophen and mephobarbital (Moderate Drug-Drug)

MONITOR: Barbiturates may increase the hepatotoxic potential of acetaminophen and decrease its therapeutic effects. The mechanism may be related to accelerated CYP450 metabolism of acetaminophen with consequent increase in hepatotoxic metabolites. This interaction is of greatest concern in cases of acetaminophen overdose.

MANAGEMENT: Monitoring for altered efficacy and safety is recommended. Prolonged use or high doses of acetaminophen should be avoided by patients on barbiturate therapy.