memantine and Artane Interactions

Interactions between memantine and Artane (trihexyphenidyl)

trihexyphenidyl and memantine (Moderate Drug-Drug)

ADJUST DOSE: The concomitant use of memantine may potentiate the anticholinergic effects of trihexyphenidyl such as dry mouth, blurry vision, or urinary hesitancy. The mechanism is unknown. Clinical data have not been reported.

MANAGEMENT: Patients should be monitored for adverse effects. Dose adjustments of the anticholinergic agent may be required during coadministration.