melatonin and Mibefradil Interactions

Interactions between melatonin and Mibefradil (mibefradil)

melatonin and mibefradil (Minor Drug-Drug)

In vitro studies indicate that mibefradil inhibits the metabolism of drugs that are substrates of the CYP450 1A2 microsomal pathway. This may result in elevated plasma concentrations of these drugs. The manufacturer reports no pharmacokinetic interaction was observed when theophylline, a known substrate of CYP450 1A2, was studied with mibefradil. However, until specific information is available, observation for altered clinical and laboratory effects is recommended if these agents must be used with mibefradil.