megace and Tikosyn Interactions

Interactions between megace(megestrol) and Tikosyn (dofetilide)

megestrol and dofetilide (Major Drug-Drug)

CONTRAINDICATED: The major pathway for elimination of dofetilide is through glomerular filtration and active tubular secretion using the cation transport system. When dofetilide is used in combination with another medication that inhibits the cation transport system, significant increases in dofetilide plasma concentrations and/or Cmax may result. Higher plasma levels increase the risk of dofetilide-induced arrhythmias.

MANAGEMENT: The manufacturer considers the concomitant use of these drugs contraindicated.