Drug interactions between Medrol and methotrexate
Results for the following 2 drugs: |
|
|---|---|
| Medrol (methylprednisolone) | |
| methotrexate | |
Interactions between your selected drugs
methotrexate ⇔ methylprednisolone
Applies to: methotrexate and Medrol (methylprednisolone)
MONITOR: Although they are often used together in clinical practice, limited data suggest that corticosteroids may increase the risk of methotrexate toxicity. Individual cases of severe and fatal bone marrow suppression and fatal systemic moniliasis have been reported. Data have been conflicting. A pediatric study found no increased methotrexate toxicity; however, hepatic enzyme elevations were noted. The mechanism is unknown.
MANAGEMENT: Close monitoring for signs and symptoms of bone marrow suppression and nephrotoxicity is advisable during concomitant administration. Patients should be advised to report possible symptoms of toxicity including nausea, vomiting, diarrhea, stomatitis, sore throat, chills, fever, rash, unusual bruising or bleeding, jaundice, dark urine, swelling of the extremities, or shortness of breath to their physician.
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