marinol and Orlaam Interactions

Interactions between marinol(dronabinol) and Orlaam (levomethadyl acetate)

dronabinol and levomethadyl acetate (Major Drug-Drug)

MONITOR CLOSELY: The concurrent use of levomethadyl acetate and other central nervous system (CNS) depressants may result in additive CNS and respiratory depression, hypotension, sedation, or coma.

MANAGEMENT: Caution and reduced dosages are recommended if CNS depressants are prescribed to patients on levomethadyl acetate maintenance. Alcohol should be avoided. Patients who are known to abuse sedatives, tranquilizers, antidepressants, benzodiazepines, and alcohol should be warned of the risk of serious and potentially fatal overdose if these substances are taken concurrently.