Drug interactions between Macrodantin and Urispas
Results for the following 2 drugs: |
|
|---|---|
| Macrodantin (nitrofurantoin) | |
| Urispas (flavoxate) | |
Interactions between your selected drugs
nitrofurantoin ⇔ flavoxate
Applies to: Macrodantin (nitrofurantoin) and Urispas (flavoxate)
Anticholinergic agents may increase the absorption and oral bioavailability of nitrofurantoin. The proposed mechanism involves increased gastrointestinal transit time due to reduction of stomach and intestinal motility by anticholinergic agents. In six healthy volunteers, pretreatment with propantheline 45 minutes before a single 100 mg dose of nitrofurantoin significantly increased the oral bioavailability of nitrofurantoin as indicated by a 68% increase in urinary recovery. In another study, atropine 500 mcg given subcutaneously one-half hour before a single 100 mg dose of nitrofurantoin delayed the absorption and urinary excretion of nitrofurantoin but did not affect its overall bioavailability in ten healthy volunteers. The clinical significance of these changes is unknown.
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