loratadine and Nefazodone Interactions

Interactions between loratadine and Nefazodone (nefazodone)

loratadine and nefazodone (Moderate Drug-Drug)

MONITOR: Coadministration with nefazodone may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by nefazodone.

MANAGEMENT: Caution is advised if nefazodone must be used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. A lower initial dosage, as well as clinical and laboratory monitoring, may be appropriate for some drugs.